Conversion of DL-lactate-2-C14 or -3-C14 or pyruvate-2-C14 to blood glucose in humans: effects of diabetes, insulin, tolbutamide, and glucose load.
نویسندگان
چکیده
منابع مشابه
Studies on Experimental Diabetes
Experimental diabetes has been characterized as a metabolic state involving both overproduction and underutilization of glucose. Although these changes have been recognized for many years, the specific biochemical alterations resulting in increased hepatic glucose production have not been adequately described. The adrenal cortical steroids are known, however, to have an important role in the re...
متن کاملEffect of fructose on lipogenesis from lactate and acetate in diabetic liver.
Defective glucose utilization in the liver of the glucose-fed diabetic rat has been stated to be the result of at least two blocks: one, at an early stage in glycolysis, probably hexokinase; the other, in the synthesis of fatty acids from the Z-carbon-like intermediate. This conclusion was based on the following observations: (1) the conversion of C14-glucose to CO2 was depressed in the liver o...
متن کاملEffect of Fructose on Lipogenesis from Lactate and Acetate in Diabetic Liver*
Defective glucose utilization in the liver of the glucose-fed diabetic rat has been stated to be the result of at least two blocks: one, at an early stage in glycolysis, probably hexokinase; the other, in the synthesis of fatty acids from the Z-carbon-like intermediate. This conclusion was based on the following observations: (1) the conversion of C14-glucose to CO2 was depressed in the liver o...
متن کاملConversion of Glutamate Carbon to Fatty Acid Carbon via Citrate in Rat Epididymal Fat Pads.
The incorporation of the C14 of glutamate-2-CI4 and glutamate-5-C14 into fatty acids by epididymal fat pads and liver slices suggests the operation of the following metabolic pathway : a-ketoglutarate + isocitrate -+ cbaconitate + citrate + acetyl CoA + oxalacetate (referred to as the backward reaction of the Krebs cycle). Fatty acid-C14 recoveries from glutamate-2-C14, glutamate5-C14, and acet...
متن کاملEvaluation of catabolic pathways of glucose in mammalian systems.
Earlier studies from this laboratory have shown that free gluconic acid is extensively oxidized to COZ and converted in part to glucose by the intact rat. The production of free gluconic acid, however, could not be detected (I). The major pathway of gluconate catabolism involves decarboxylation at carbon atom 1 and utilization of the residue of the molecule for glucogenesis (2). Reduction of gl...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 42 شماره
صفحات -
تاریخ انتشار 1963